An eclectic musician, he graduated with honors in Piano with M° Tiziana Silvestri and Conducting with M° Nicola H. Samale at the Conservatory G. Martucci of Salerno. He earned his Master's degree in Musical Analysis at the University of Calabria and his Postgraduate degree in Conducting at the Musik und Kunst Privatuniversität der Stadt Wien with M° Andreas Stoehr. He specialized with M° Daniele Agiman at the Musici di Parma Academy and Conservatorio G. Verdi in Milan. He is professor of piano at the Conservatory G. Martucci of Salerno.

He is active in the world of research with a project focused on Domenico Scarlatti, participating in conferences in Italy, Spain and Portugal. In the 2019/2020 academic year, he was the winner of a research grant at the G. Martucci Conservatory of Salerno with a project entitled "Towards the Classical Sonata Form." He collaborates regularly witn the musicological journal "Il Mondo della Musica" by Maria Elisa Tozzi and other Italian and foreign journals, and is the author of numerous essays and publications in the musicological-analytical field.

Alfonso Todisco is the artistic and musical director of the Artemus Orchestra of Pompei, which boasts numerous important concerts in the area, six concert seasons and two albums produced by Satyr MB Production: "Gli echi dell'eterna bellezza" with music inspired by ancient Pompeii by F. Cuccurullo, A. Onorato, P. Odierna and N. H. Samale, presented in December 2019; "Il Prodigio" with three of F. Mendelssohn's twelve symphonies for strings, released in October 2020.

In September 2022 he released his new album recorded with the KLK Symphony Orchestra in Lviv, on the Da Vinci Classics label, featuring string serenades by Dvořák and Tchaikovsky.

Alfonso Todisco conducted the Orchestra de chambre de Paris, KLK Symphony Orchestra (Lviv), Orchestra Filarmonica G. Verdi di Salerno, Vidin Symphony Orchestra, Joven Orquestra de Leòn, Musici di Parma Orchestra, Nuova Orchestra Scarlatti, Orchestra Sinfonica Città di Roma, Orchestra da Camera Abruzzese, Pleven Symphony Orchestra, MUK Symphony Orchestra of Vienna, Orchestra Sinfonica di Sanremo. He is assistant conductor of M° Giacomo Sagripanti.

In 2022 he conducted Il Barbiere di Siviglia and Lucia di Lammermoor at the Ruse State Opera (Bulgaria), and in June 2023 he made his debut with La Traviata at the National Opera and Ballet in Constanta (Romania).